Proven by Research

How TBX-Free & TBX Vape-Free Work: A Scientifically Backed, Natural Solution to Quit Smoking and Vaping

TBX-Free and TBX Vape-Free are designed to help individuals quit smoking and vaping through a safe, natural, and clinically validated approach. The key active ingredient in both products is cytisinicline, a plant-based alkaloid that is non-addictive and has been safely used in smoking cessation efforts for decades across Europe.

Cytisinicline works by targeting and blocking nicotine receptors in the brain, thereby reducing the pleasurable effects of nicotine and significantly lowering cravings and withdrawal symptoms. This unique mechanism helps disrupt the cycle of nicotine dependence without the use of nicotine replacement therapies.

The ORCA-3 clinical study, published in JAMA Internal Medicine (2025), highlighted the efficacy of cytisinicline in a rigorous, placebo-controlled trial. Over a 12-week regimen, participants taking cytisinicline achieved a continuous abstinence rate of 20.5%, compared to just 4.2% in the placebo group. These results clearly demonstrate cytisinicline’s effectiveness and excellent tolerability, with minimal side effects reported.

Unlike many other cessation aids, TBX-Free and TBX Vape-Free are nicotine-free, non-addictive, and derived from natural sources, making them a safer long-term solution for those looking to break free from nicotine dependence. Whether you're trying to quit cigarettes or vaping, these products offer a scientifically supported and plant-powered pathway to a healthier, nicotine-free life.